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La controverse existante quant aux mesures de prévention résulte de plusieurs facteurs: la difficulté de prédire l’étendue de la transmission lors de l’introduction d’une souche MRSA dans un établissement, l’endémicité du MRSA varie d’un établissement à l’autre et d’une région à l’autre, l’éradication du MRSA dans un établissement peut être difficile voire impossible, le manque de données sur l’efficacité particulière de chacune des mesures de prévention et de contrôle, car plusieurs de ces mesures sont appliquées simultanément, le manque de données sur les coûts liés à l’application des mesures de prévention par rapport à ceux engendrés par l’infection à MRSA, l’inégalité des établissements dans leurs caractéristiques (types de patients, types de soins types de services) fait varier les stratégies de prévention. 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